Proliferative changes in the oral cavity are usually caused by prolonged mechanical irritation or post-traumatic changes. Most commonly, they occur in the elderly (e.g. due to improper denture fit, orthodontic appliances). All changes must be closely observed. If, after two weeks, no significant improvement is observed due to taking pharmaceuticals, a histopathological examination is performed, which determines whether the changes are cancerous. In the case of detecting proliferative changes (cancer), it usually becomes necessary to perform surgical intervention.
Other changes in the oral cavity which can develop into inflammatory or proliferative changes are, for example, aphthous ulcers. When conservative treatment in the form antiseptic administration does not bring any results, they should be diagnosed by a histopathological examination.